解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:OBJECTIVE:To examine glycemic control for the prevention of retinopathy in early diagnosed Japanese NIDDM patients. RESEARCH DESIGN AND METHODS:There were 137 patients with NIDDM but without retinopathy who first visited our facility from 1983-1985. Their age at diagnosis ranged from 30-65 years, with a disease durati...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.4.621
更新日期:1997-04-01 00:00:00
abstract::Severe hypoglycemia (SH) is a significant problem for many patients with type I diabetes and presents a major barrier to optimal diabetes control. A critical task facing diabetes research is to understand, predict, and reduce the risk of SH in insulin-treated patients. The purpose of this article is to propose a biops...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.4.661
更新日期:1997-04-01 00:00:00
abstract:OBJECTIVE:Recipients of solid organ transplants have an increased risk of developing certain types of malignancies as compared with the general population. The majority of the literature has reported on neoplasms in kidney and heart transplant recipients. RESEARCH DESIGN AND METHODS:We describe 9 neoplasms occurring i...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.3.272
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence and incidence of diabetes in Alaska Natives and the incidence of cerebrovascular accidents (stroke), myocardial infarction (MI), end-stage renal disease (ESRD), lower-extremity amputations (LEA), and mortality over a 6- to 8-year period. RESEARCH DESIGN AND METHODS:The data derive...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.3.314
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVE:To examine if dual replacement with insulin and rhIGF-I, recombinant human insulin-like growth factor I (rhIGF-I) may be safe and result in improved metabolic control and reduced insulin usage. RESEARCH DESIGN AND METHODS:Forty-three patients with IDDM were randomized to receive a daily injection of rhIGF-I ...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2337/diacare.20.3.374
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the relationship between renal function, ambulatory blood pressure (AMBP), and glycemic control in microalbuminuric IDDM patients compared with normoalbuminuric patients. RESEARCH DESIGN AND METHODS:Nineteen male patients (age 33 +/- 6 years) with slight microalbuminuria (UAE 20-70 micrograms/min...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.3.429
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of normal aging on the protective responses against hypoglycemia, in view of the fact that type II diabetes is primarily a disease of aging, and its treatment is associated with risk of hypoglycemia with cognitive impairment. RESEARCH DESIGN AND METHODS:Plasma glucose was lowered st...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.2.135
更新日期:1997-02-01 00:00:00
abstract:OBJECTIVE:To characterize the relationship of subclinical and clinical eating disorders to HbA1c values in women with IDDM. RESEARCH DESIGN AND METHODS:Ninety women with IDDM (18-46 years of age) were recruited from diabetes clinics throughout Connecticut and Massachusetts. Subjects were categorized into one of three ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.2.182
更新日期:1997-02-01 00:00:00
abstract:OBJECTIVE:To examine central nervous system involvement as a possible complication of diabetes by performing a comprehensive neuropsychological evaluation of relatively young (age < 55 years) NIDDM patients and a group of control subjects. RESEARCH DESIGN AND METHODS:A cross-sectional comparative study of 28 patients,...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.1.32
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:To determine the proportion of patients with gestational diabetes mellitus (GDM) who have serological characteristics typical of IDDM. RESEARCH DESIGN AND METHODS:Islet cell antibodies (ICAs), insulin autoantibodies (IAAs), GAD65, and IA-2 antibodies were measured in 145 pregnant women with GDM, 33 with impa...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.1.81
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the effectiveness of systemic hyperbaric oxygen therapy (s HBOT) in addition to a comprehensive protocol in decreasing major amputation rate in diabetic patients hospitalized for severe foot ulcer. RESEARCH DESIGN AND METHODS:From August 1993 to August 1995, 70 diabetic subjects were consecutivel...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.19.12.1338
更新日期:1996-12-01 00:00:00
abstract:OBJECTIVE:To investigate the role of hyperglycemia in mediating the clinical association of NIDDM with hypertension and left ventricular dysfunction and hypertrophy. RESEARCH DESIGN AND METHODS:Since hyperglycemia elevates cytosolic free calcium (Cai) both in myocardial and vascular smooth muscle cells, we utilized nu...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.19.12.1393
更新日期:1996-12-01 00:00:00
abstract:OBJECTIVE:The pharmacokinetics and glucodynamics of a new insulin analog, insulin lispro, and regular human insulin were compared and contrasted after subcutaneous administrations in femoral, deltoid, and abdominal injection sites. RESEARCH DESIGN AND METHODS:Single 0.2 U/kg doses of insulin lispro and regular insulin...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.19.12.1437
更新日期:1996-12-01 00:00:00
abstract:OBJECTIVE:To investigate the long-term antidiabetogenic effect of glucagon-like peptide 1 (GLP-1) and its influence on diabetic dyslipoproteinemia, patients with NIDDM were treated with GLP-1 subcutaneously for 1 week. RESEARCH DESIGN AND METHODS:Twelve patients participated in the study. The 1st week of the study, al...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.19.11.1200
更新日期:1996-11-01 00:00:00
abstract:OBJECTIVE:To compare the duration of healing of foot ulcers with osteomyelitis in diabetic patients treated by medical treatment versus medical treatment associated with conservative orthopedic surgery. RESEARCH DESIGN AND METHODS:We entered into the study 67 diabetic patients who had a foot ulcer with osteomyelitis w...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.19.11.1257
更新日期:1996-11-01 00:00:00
abstract::The scientific literature demonstrates that fat replacers have a reasonable certainty of no harm. Whether they help produce desired health outcomes, i.e., decreased risk of coronary heart disease and certain types of cancer related to excess fat intake, weight reduction, changes in lipid profile, improved glycemic con...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.19.11.1294
更新日期:1996-11-01 00:00:00
abstract:OBJECTIVE:Platelet hyperfunction is a typical feature of the prothrombotic state that frequently complicates the natural history of diabetes. In uremia, a bleeding diathesis is present, which principally involves the primary phase of hemostasis. Thus, in patients with uremia of diabetic origin, the infrequent coexisten...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.19.10.1062
更新日期:1996-10-01 00:00:00
abstract:OBJECTIVE:The mechanisms by which diabetes leads to rapidly progressive atherosclerosis are not fully understood. Adherence of monocytes to the arterial wall is an early event in the development of atherosclerotic lesions. RESEARCH DESIGN AND METHODS:The binding of freshly isolated monocytes from patients with NIDDM, ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.19.10.1122
更新日期:1996-10-01 00:00:00
abstract:OBJECTIVE:Little is known about medial arterial calcification (MAC) other than its association with age, sex, diabetes, and diabetes complications. Familial aggregation of this disorder was studied to determine the importance of potential genetic factors and to assess whether such familial aggregation was independent o...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.19.9.968
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVE:To determine whether increasing doses (amounts) of beta-glucan present in an extruded breakfast cereal affect the glycemic and insulinemic responses in eight NIDDM subjects, compared with the same responses after a continental breakfast (bread, milk, cheese, ham). RESEARCH DESIGN AND METHODS:Breakfast cereal...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.19.8.831
更新日期:1996-08-01 00:00:00
abstract:OBJECTIVE:To investigate the basis of central nervous system dysfunction in diabetes associated with the 3243 mitochondrial tRNA mutation, we studied neuroimaging findings in patients with this disease. RESEARCH DESIGN AND METHODS:We screened 205 diabetic patients. Those patients who had the 3243 mutation in leukocyte...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.19.7.739
更新日期:1996-07-01 00:00:00
abstract:OBJECTIVE:To examine the predictors of lower extremity amputation in patients with NIDDM. RESEARCH DESIGN AND METHODS:At baseline, risk factors for amputation were determined in 1,044 NIDDM patients (571 men, 473 women) aged 45 to 64 years. These patients were followed up to 7 years with respect to amputation. RESULT...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.19.6.607
更新日期:1996-06-01 00:00:00
abstract:OBJECTIVE:To assess the prevalence of diabetes and impaired glucose tolerance (IGT) in the adult population of Rio de Janeiro, a two-stage cross-sectional survey was carried out in a random sample of 2,051 individuals aged 30-69 years from Rio de Janeiro city in Brazil. RESEARCH DESIGN AND METHODS:Subjects were first ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.19.6.663
更新日期:1996-06-01 00:00:00
abstract:OBJECTIVE:To compare the weight losses of black and white patients with NIDDM treated in a year-long behavioral weight loss program. RESEARCH DESIGN AND METHODS:Subjects were randomly assigned to a behavioral program that either used a low-calorie diet throughout or included two 12-week periods of a very-low calorie d...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.19.5.409
更新日期:1996-05-01 00:00:00
abstract:OBJECTIVE:Supplementation of type II diabetic diets with n-3 fatty acids (FAs) from fish oil (FO) has been associated with lowered triglyceride and VLDL levels, although reports of impaired glycemic control have limited their use. Effects of n-3FAs from nonmarine sources are less well documented. Therefore, an investig...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.19.5.463
更新日期:1996-05-01 00:00:00
abstract::Historically, alcohol use by the diabetic patient has been controversial. Recent studies in the general population have shown an improvement in mortality with moderate alcohol intake (one to three drinks per day). This improved mortality is greatest in those individuals who have a higher risk of ischemic heart disease...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.19.5.509
更新日期:1996-05-01 00:00:00
abstract:OBJECTIVE:To investigate neurophysiological alterations of higher brain function in patients with NIDDM. RESEARCH DESIGN AND METHODS:Auditory P300 event-related potentials were recorded in 60 NIDDM patients who had no evidence of stroke, dementia, or any other neurological illnesses. The P300 wave latencies in diabeti...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.19.4.360
更新日期:1996-04-01 00:00:00
abstract::The role of hyperinsulinemia in the pathogenesis of triglyceride (TG) and VLDL over-production in insulin-resistant states remains controversial. While studies in humans and animals have generally suggested that chronic hyperinsulinemia facilitates VLDL production, particularly in the presence of an abundant supply of...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.19.4.390
更新日期:1996-04-01 00:00:00
abstract:OBJECTIVE:To determine the effect of diabetes on thyroid hormone and thyroxine-binding globulin (TBG) concentrations during puberty. RESEARCH DESIGN AND METHODS:Total thyroxine (TT4), free thyroxine (FT4), and TBG levels of 171 thyroid microsomal antibody-negative subjects with normal thyroid-stimulating hormone (TSH)...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.19.3.246
更新日期:1996-03-01 00:00:00
abstract:OBJECTIVE:Treatment of IDDM in youth emphasized balancing children's self-care autonomy with their psychological maturity. However, few data exist to guide clinicians or parents, and little is known about correlates of deviations from this ideal. RESEARCH DESIGN AND METHODS:In this cross-sectional study, IDDM self-car...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.19.2.119
更新日期:1996-02-01 00:00:00
abstract:OBJECTIVE:A 1-year randomized prospective study was conducted to investigate the efficacy of feedback from split-sample testing as part of a capillary blood glucose quality assurance program. RESEARCH DESIGN AND METHODS:A total of 124 nurses were randomized to either group A (quarterly comparisons with feedback) or gr...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.19.2.168
更新日期:1996-02-01 00:00:00
abstract:OBJECTIVE:It has proved difficult to separate the role of the diabetic state as distinct from its complications in causing the elevation in erythrocyte sodium-lithium (Na-Li) countertransport activity that has been observed in diabetes. The present study sought to isolate the impact of diabetes on the countertransporte...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.19.1.32
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVE:To determine the value of measuring serum triglyceride (TG) levels early in pregnancy for predicting late-gestation glucose tolerance and neonatal birth weight ratio (BWR) (birth weight corrected for gestational age). RESEARCH DESIGN AND METHODS:The relationships between morning nonfasting TG measured early ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.18.12.1550
更新日期:1995-12-01 00:00:00
abstract::The economic burden of diabetes in the U.S. is now more than 90 billion dollars per year (113-115). In the diabetes community, there is a feeling that aggressive measures to detect diabetes in earlier stages may be warranted. Regardless of whether evidence is convincing that there are benefits from early detection of ...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.18.12.1606
更新日期:1995-12-01 00:00:00
abstract:OBJECTIVE:To compare peak pressures on the sole of the foot in non-insulin-dependent diabetic patients with isolated, unilateral amputations of the great toe and first metatarsal with the patients' contralateral, intact foot. RESEARCH DESIGN AND METHODS:Eleven patients with a unilateral great toe and partial first met...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.18.11.1460
更新日期:1995-11-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of ginseng on newly diagnosed non-insulin-dependent diabetes mellitus (NIDDM) patients. RESEARCH DESIGN AND METHODS:In this double-blind placebo-controlled study, 36 NIDDM patients were treated for 8 weeks with ginseng (100 or 200 mg) or placebo. Efficacy was evaluated with psychoph...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究
doi:10.2337/diacare.18.10.1373
更新日期:1995-10-01 00:00:00
abstract:OBJECTIVE:The prevalence of systemic hypertension is increased in patients with diabetes. In this prospective, randomized, crossover clinical trial, we assessed antihypertensive effects of chronic intermittent intravenous insulin therapy (CIIIT) on insulin-dependent diabetes mellitus (IDDM) subjects with hypertension a...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.18.9.1260
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVE:To compare platelet plasminogen activator inhibitor 1 (PAI-1) release in type II diabetic patients and healthy control subjects. RESEARCH DESIGN AND METHODS:We studied a group of 27 diabetic patients and a group of 16 nondiabetic control subjects. Whole-blood platelet aggregation, defined as a decrease in pl...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.18.8.1150
更新日期:1995-08-01 00:00:00
abstract:OBJECTIVE:To examine the factors that determine the blood pressure response to enalapril and nifedipine monotherapy in the treatment of hypertension associated with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:After a 6-week placebo baseline period, 102 hypertensive NIDDM patients were ...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.18.7.1001
更新日期:1995-07-01 00:00:00
abstract:OBJECTIVE:To determine the incidence of insulin-dependent diabetes mellitus (IDDM) in children aged 0-14 years in Kuwait, as part of the World Health Organization Multinational Collaborative Study (DIAMOND), and to determine if the incidence rates have increased. RESEARCH DESIGN AND METHODS:All cases of IDDM diagnosed...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.18.7.923
更新日期:1995-07-01 00:00:00